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ea0011oc6 | Signal transduction OC1 Novartis Oncology Young Investigator Award | ECE2006

Activation of androgen membrane binding sites induce potent regression of prostate cancer cells in vitro and in vivo

Papadopoulou N , Kampa M , Gravanis A , Castanas E , Stournaras C

Recent data indicate that steroid action can be completed through genomic (late) and non-genomic (rapid) mechanisms. Non-genomic androgen effects are initiated at the membrane level and imply specific secretory and signaling mechanisms different from the classical intracellular androgen receptor activation. In previous work we have reported that androgen membrane binding sites (Ambs) are present in LNCaP human prostate cancer cells. Their activation mediates a FAK/PI3K/Cdc42/R...

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ea0044oc1.3 | Early Career Oral Communications | SFEBES2016

Investigating the interaction between KNDy peptides on gonadotrophin release in humans – novel findings with therapeutic importance

Narayanaswamy Shakunthala , Prague Julia K , Jayasena Channa N , Papadopoulou Deborah A , Mizamtsidi Maria , Shah Amar J , Bassett Paul , Comninos Alexander N , Abbara Ali , Bloom Stephen R , Veldhuis Johannes D , Dhillo Waljit S

Background: Hypothalamic KNDy neurons have recently been identified as key regulators of reproductive function by releasing three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin. Animal studies show they interact to control pulsatile GnRH release, which is vital for fertility. In animals, kisspeptin stimulates, NKB modulates and the opioid dynorphin inhibits GnRH pulsatility. However, the interaction of these peptides has never been studied in humans. To inve...

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Endocrine Abstracts

Activation of androgen membrane binding sites induce potent regression of prostate cancer cells in vitro and in vivo

Investigating the interaction between KNDy peptides on gonadotrophin release in humans – novel findings with therapeutic importance

BiosciAbstracts